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  • Breast Cancer Adjuvant Therapy - Adriamycin + Cyclophosphamide

    USED WHEN? Used as a combination add-on (adjuvant) chemotherapy to treat breast cancer patients with auxiliary lymph node involvement after surgical removal of the primary cancer. DOSAGE ●Adriamycin (doxorubicin) is administered at 40 to 75 mg/m2 when administered in combination chemotherapy. ●Cyclophosphamide capsules are 25 mg or 50 mg. It can also be administered via infusion. Hydration is very important to reduce the risk of urinary tract toxicity. A total of 4 cycles of AC is administered every 21 days. Overdosing may happen. Takes 3-4 weeks to recover. MECHANISM OF ACTION ●Adriamycin inhibits cell proliferation and in duces DNA strand breaks in cells. ●Cyclophosphamide is a prodrug, which is processed in the liver. The products induce covalent crosslinks in cellular DNA, which inhibits replication and induces cell death. Both of these drugs are cytotoxic drugs. SIDE EFFECTS ● Adriamycin related severe side effects: cardiomyopathy, cardiac arrhythmias, secondary cancers, leakage of blood vessels, tissue necrosis, severe low blood cell count, tumor lysis syndrome, radiation sensitization etc. ● Cyclophosphamide related severe side-effects: hyper-sensitivity, low blood counts, urinary tract and renal, cardiac and pulmonary toxicity, secondary cancers, infertility etc. CLINICAL STUDIES There are many clinical studies published and several meta-analyses have been performed. The following clinical study is presented in a simplified fashion. Clinical study 1 ♦ In a phase 3 clinical trial with 1016 patients who had surgically removed stage I to III invasive breast cancer, patients were treated with either doxorubicin + cyclophosphamide or with docetaxel+ cyclophosphamide. The results are as follows: ● Doxorubicin + cyclophosphamide : 5-year disease-free survival rate = 80% 5-year overall survival rate = 87% ● Docetaxel + cyclophosphamide: 5-year disease-free survival = 86% 5-year overall survival rate = 90% For more information: https://pubmed.ncbi.nlm.nih.gov/17135639 We can help you with more simplified data so that you can make informed decisions about your treatment options. Visit www.cancertherapies4u.com for more information. OTHER COMBINATIONS AC-T = Adriamycin + cyclophosphamide + taxol BREAST CANCER OUTCOME 5-year overall survival is 90% in the USA. 15% of all cancer cases is breast cancer but 7% of all cancer related mortality is due to breast cancer. There are 39 FDA-approved drugs to treat breast cancer in the USA. Sources: NCI and NIH. #breastcancer #chemotherapy #cancer #AC #cancertreatments #doxorubicin #adriamycin #cyclophosphamide ------------------------------------------------------------------------------- Author: Anirban Mukherjee, PhD The author is a scientist at the University of Texas at Austin and researches novel chemotherapeutic targets and chemotherapeutic DNA damage processing .

  • Cancer Pain - how does one manage?

    Cancer pain is experienced by 20% - 50% of the cancer patients. Why do patients experience pain from cancer? What are the best ways to manage pain from cancer? Managing cancer pain is a big part of cancer treatment. Cancer patients should clearly communicate to their oncologists about the pain they are experiencing. Communication from patients is the gold standard of accessing pain. Pain management has serious implications on the quality of life of the cancer patients. PAIN CLASSIFICATION · Acute · Chronic · Breakthrough · Nociceptive · Neuropathic · Psychogenic DRUGS TO TREAT CANCER PAIN · NSAIDs (Non-steroidal anti-inflammatory drugs) · Opioids · Add-on pain medicines · Cannabinoids OTHER OPTIONS · Massage · Chiropractic therapy · Reflexology · Reiki · Acupuncture · Scrambler therapy Detailed explanation can be found on www.cancer.gov website. You can also read up peer-reviewed journal articles on cancer pain management by visiting www.pubmed.gov. Below I will try to summarize cancer pain and give you a very basic idea of how cancer pain is clinically managed. BONE PAIN Bone pain is one of the most common causes of pain when the disease has metastasized. Most patients are prescribed morphine (or other opioids) for pain relief. NSAIDs (non-steroidal anti-inflammatory drugs) and corticosteroids are also prescribed. They are moderately effective and safe. Zoledronic acid or pamidronate or denosumab are used to reduce bone pain (skeletal events) related events. Palliative radiation therapy can cause pain relief and the effect can last up to 6 months. Surgical intervention is another option. VISCERAL PAIN Opioids remain the main form of treatment to ease pain from visceral organs, such as bladder, stomach, bowel and ureters. The main source of visceral pain may be hard to locate sometimes. NEUROPATHIC PAIN Neuropathic pain is common in cancer patients. Approximately 17% of the cancer patients receive neuropathic pain. Gabapentin is used as a monotherapy to reduce neuropathic pain. Sometimes gabapentin + opioids provide better pain relief within 4-8 days for incontrollable pain. Pregabalin is used to reduce radiation-therapy induced neuropathic pain. MASTECTOMY RELATED PAIN Venlafaxine or gabapentin or pregabalin is used with various results in reducing pain from mastectomy. POST-THORACOTOMY PAIN Pain that persists after 2 months of thoracotomy. Opioids and non-opioid analgesics are used to manage the pain. CHEMOTHERAPY-INDUCED PAIN Duloxetine is the only drug that has been systematically studied. It can help reduce pain from chemotherapy. Gabapentin does not provide any relief from pain caused by chemotherapy. Venlafaxine is used to treat neuropathy from oxaliplatin. Natural products such as acetyl-L-carnitine showed worsening of pain and the worsening persisted up to two years in some patients. **** If you want comprehensive information on cancer pain management, please check out our website for the report titled "Options To Manage Cancer Pain". #Cancer #pain #cancerpain #opioids #cannabinoids ------------------------------------------------------------------------------------- The information here has been summarized from National Cancer Institute. Follow this link if you want more information: https://www.cancer.gov/about-cancer/treatment/side-effects/pain/pain-hp-pdq#_387_toc ---------------------------------------------------------------------------------- Author: Anirban Mukherjee, PhD The author is a cancer scientist from University of Texas at Austin working on developing new drugs to treat and manage chemoresistant forms of cancer. ---------------------------------------------------------------------------------

  • Questions to ask my oncologist:

    Cancer diagnosis can be extremely stressful for patients and family members. It is natural to have a lot of questions; questions about cancer, questions about cancer treatment options and many more. Cancer treatment landscape is complicated and therefore cancer treatment related questions can be best answered by your oncologist and other health care professionals. Therefore, it is important know what cancer treatment related questions to ask your oncologist before you visit because you may not get more than 2o minutes of your doctor's time. But often, we run into the issue of "what should I ask my oncologist?" Questions for your oncologist can be very personal and you may feel hesitant to ask questions. To best use your time with your oncologist during your appointment, it is useful to have questions ready before hand and probably written down. Below is a list of some of the most popular and important questions to ask your oncologist to have a meaningful conversation. For data-driven answers to your cancer treatment related questions, you can visit www.cancertherapies4u.com or email us at tellus@cancertherapies4u.com for more information. Questions to ask your oncologist about the chosen treatment option: Why is this the best option? This is probably the most important question to ask your oncologist, because you want to know what are the numbers regarding disease-free survival, overall survival and quality of life. To treat most of the cancers, there are multiple FDA-approved cancer drugs. Not all of these drugs or drug combinations work equally well for all the patients. So it may be a great question to ask you oncologist about what treatment options are you choosing? What is the expected response rate, recurrence-free survival, progression-free survival and overall survival? Ideally, you want to choose the option that has the highest response rate, highest recurrence-free survival, progression-free survival and overall survival rates, as seen from clinical trials. In addition, your oncologist will have personal experience from treating many patients, which may help you find your answers. Questions to ask your oncologist about additional options: what if the current approach fails to produce desired results? Your oncologist or the healthcare providing team is going to provide you with a treatment plan that works for most patients based on your test results. There is a significantly high chance that this plan will work equally well for you. However, it never hurts to have a contingency plan. So may be you can bring up this question when you meet your oncologist. Ask your oncologist about the second line of treatment, third line of treatment as well as results from those treatments. Questions to ask your oncologist about side effects and pain management Another important question for your oncologist could be about management of therapy related side effects and pain. The cancer treatment is harsh. It is harsh because cancer cells keep growing and replacing normal cells from important organs and other tissues. So eventually the patient dies from multiple organ failure. Only a harsh treatment is effective in stopping these highly dividing cells. Therefore, it is important to discuss the side effects of the proposed treatment and how well does it align with your health history. Now remember, although it may sound intimidating, these drugs have been prescribed and studied millions of times to provide significant clinical benefit to patients. You may have heard that chemotherapy is very toxic for the body and has long term effects. Yes it is true, but the effects are reversible and the benefit outweighs the risk. Same is true for immunotherapy. Questions to ask your oncologist about available genetic testing Immunotherapy is becoming increasingly popular in treating several cancers. However, it is also becoming evident that the higher the tumor mutation burden is, the better the response could be from immunotherapy treatment. In addition, there are many targeted therapies available for many types of mutations, which can be determined through sequencing of the cancer genome. Liquid biopsies are becoming increasingly popular in monitoring the free floating cancer cells in the blood. Over a period of time the change in the mutation level in these free floating cancer cells can be an indicator of tumor progression or relapse. Ask your doctor about how to get the cancer genome sequenced. Questions to ask your oncologist about clinical trials and how to get enrolled Clinical trials are one of the best ways to get effective cancer care. Ask your doctor if you can enroll in a clinical trial. Questions to ask your oncologist about pain management With cancer and cancer treatment come a lot of pain. So pain management on its own is a big area that needs to be discussed with your doctor. Questions to ask your oncologist about coping with the feelings that come with cancer Ask your doctor about how to manage all the overwhelming feelings that come with cancer and cause psychological distress. Ask your doctor about available help with adjusting to cancer in your daily life. There will always be questions during the treatment and after the treatment. You can always contact Cancer Therapies 4 U for your information related needs. We can research information from published clinical literature and/or analyze published large-scale patient datasets to provide you with important insights, which will definitely help you to make an informed decision. #cancer #oncologist #cancerquestions ----------------------------------------------------------------------------------Source: Cancer.gov www.cancertherapies4u.com ---------------------------------------------------------------------------------- Author: Anirban Mukherjee, PhD Founder, Cancer Therapies 4 U LLC The author is a cancer Scientist at The University of Texas at Austin researching new drugs to treat chemoresistant forms of cancer.

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  • Cancer treatment options | Cancer treatment results

    DO YOU HAVE Cancer treatment-related questions? We help cancer patients make informed decisions by making data analysis available to them. Published clinical trials data, cancer mutation data and meta-analyses can give cancer patients a better idea about the outcome of cancer treatments. Such data-driven answers to address cancer treatment related questions including surgery, radiation, chemotherapy, immunotherapy, targeted therapy, hormone therapy, combination therapy, alternative therapy to cure and manage 28 different types of cancer to help cancer patients make informed decisions. ​ Cancer is not a death sentence anymore. In the past 25 years the cancer mortality rate has dropped by 25% in the USA . There are 33 types of cancers seen most frequently. Fifteen percent of all cancer cases in the US is breast cancer, which has 39 FDA-approved drugs leading to a 5-year survival rate of ~ 90% . In contrast, 13% of all cancer cases in the US is lung cancer , which is responsible for 25% of all cancer related deaths. The 5-year survival rate for lung cancer patients is ~20% with 36 FDA-approved drugs available for treatment. But, that survival rate is improving and nearing 50% with all the new immunotherapy , targeted cancer therapy and new disease management methods. Our understanding of cancer genomics is shaping the cancer treatment approach as well as the outcome. Inclusion of liquid biopsies and monitoring the number and the sequence of cell-free circulating tumor DNA is becoming increasingly common to monitor cancer progression. Through NextGen sequencing, learning about the cancer mutation burden is becoming increasingly helpful in determining therapeutic approaches. ​ We provide a wide range of scientific consultation services for cancer patients to fulfil their need for latest medical and scientific information. Services we provide for cancer patients 1. S ummary reports on FDA-approved cancer treatments for individual cancers - Priority Reports ($25.00 per report) 2. Patient-specific report - Advanced Reports ($200.00 per report) ​ 3. FACE-TO-FACE CONSULTATION ($500.00 per session) Who are we? We are a very unique group of scientific consultants that will bring you the most relevant information in a most meaningful way. Our scientific consultants are highly educated scientists with direct cancer research and drug discovery experience. In addition, we have a lot of experience with bioinformatics and big data analysis to find meaningful answers to your cancer treatment related questions. We help cancer patients become great self advocates . ​ The founder of Cancer Therapies 4 U LLC is Anirban Mukherjee. He has a doctorate degree in Molecular Biology from Louisiana State University and has over 10 years of cancer research experience. Currently he is a research scientist at the University Of Texas at Austin and is trying to develop a drug to treat chemoresistant forms of solid tumors. FDA-approved cancer treatments Breast Cancer Lung cancer Prostate Cancer Ovarian Cancer Pancreatic Cancer Brain cancer Brain Cancer Bladder Cancer Colon Cancer More Ask us your questions Don't just Google. Get proper information and explanation for a better understanding. Make informed decisions. Don't get scammed with expensive unapproved cancer treatments Follow -up cancer care Customize your follow-up care plan with us. Be your own advocate. Cancer Genomics How do cancer mutations affect overall survival? Cancer pain management Alternative cancer treatments Cancer diet & supplements OUR VISION To demystify cancer treatments for cancer patients. Our vision is to help all cancer patients globally with latest information so that they can learn about their cancer treatment options . We want to help cancer patients become better advocates for themselves and make informed decisions together with their doctors. We help cancer patients understand the complicated and frequently changing information landscape. CANCER TREATMENTS AND OUTCOMES: SPECIAL REPORTS Reports on cancer statistics, diagnostics, treatment approaches, FDA-approved drugs, treatment outcomes, side effects, clinical trials for individual cancers. Quick View Breast Cancer Treatment Options And Outcomes - resource for patients Price $25.00 Quick View Prostate Cancer Treatment Options and Outcomes - information for patients Price $25.00 Quick View Lung Cancer Treatment Options And Outcomes - information resource for patients Price $25.00 Quick View Ovarian Cancer Treatment Options & Outcomes - information resource for patients Price $25.00 Quick View Brain Cancer Treatment Options and Outcomes - information resource for patients Price $25.00 Quick View Pancreatic Cancer Treatment Options & Outcomes - info & resource for patients Price $25.00 Quick View Breast Cancer Treatment Options And Outcomes - resource for patients Price $25.00 Quick View Prostate Cancer Treatment Options and Outcomes - information for patients Price $25.00 Quick View Lung Cancer Treatment Options And Outcomes - information resource for patients Price $25.00 Quick View Ovarian Cancer Treatment Options & Outcomes - information resource for patients Price $25.00 Quick View Brain Cancer Treatment Options and Outcomes - information resource for patients Price $25.00 Quick View Pancreatic Cancer Treatment Options & Outcomes - info & resource for patients Price $25.00 Myths about cancer treatments Choose evidence based therapeutic approaches CAN HIGH DOSES OF VITAMIN C REPLACE CHEMOTHERAPY, RADIOTHERAPY, IMMUNOTHERAPY AND TARGETED THERAPY? No. There is no clinical evidence to support this theory. Chemotherapy/radiation therapy cannot be replaced with high doses of any vitamin. Vitamins do not treat cancer. "CHEMOTHERAPY IS POISON AND IT KILLS THE PATIENT FASTER" C hemotherapy does not kill you faster. It is true that chemotherapeutic drugs are toxic to the cells but all the FDA approved chemotherapeutic drugs show survival benefit over no treatment. "CANNABIS OIL CAN CURE CANCER" No. Recent meta analysis of patients suggests that cannabis and cannabinoids does not help in cancer regression. In fact, use of cannabis products reduces the clinical benefit of immunotherapy in some instances. Cannabis may lower the side effects of cancer and cancer treatments. "HERBAL MEDICINE WORKS BETTER WITHOUT THE SIDE EFFECTS." No. There is no such evidence that proves clinical benefit with herbal remedies over chemotherapy, immunotherapy, targeted therapy and other forms of therapy. "THE GOVERNMENT AND THE PHARMA COMPANIES HAVE THE CURE FOR CANCER ALREADY!" No. No one has the cure for cancer, yet. But cancer treatment is getting better everyday. Breakthrough treatments are being discovered faster than ever before. Cancer is not a death sentence anymore. "SURGERY AND BIOPSY CAN CAUSE THE CANCER TO SPREAD FASTER" No. Cancer cells undergo a physiological changes before they start spreading, which is called "transformation". Surgery or biopsy has nothing to do with it. ARE THERE DOCTORS IN MEXICO AND GERMANY WHO CURE ADVANCED CANCERS WITH SECRET IMMUNOTHERAPY? Best cancer treatments are provided in the USA. The US FDA properly evaluates the efficacy of a drug and approves it. Cancer patients need to make informed decisions before choosing to get treatments that are not FDA-approved. There are many scammers who use the vulnerability of cancer patients and sell them treatments. "CHEMOTHERAPY AND RADIATION THERAPY CAN CAUSE CANCER" Chemotherapy and radiation therapy sometimes can cause secondary cancer . But the risk outweighs the benefit. Without the treatment, the lifespan of the cancer patient will be much shorter. Contact Us We can help you make sure that you are getting the best cancer treatment by using our data driven approach. Contact us with any cancer related questions you have. We can be your cancer coach. We are based out of Austin, Texas, USA. Email: tellus@cancertherapies4u.com Phone: +1 512-366-0888 | Monday - Friday 8:00 am - 6:00 pm CST Name Email Subject Leave us a message... Submit Thanks for submitting!

  • Cancer therapies simplified for patient education | www.cancertherapies4u.com

    How can cancer genomics help with cancer treatments? Liquid biopsies are able to identify tumor cells and circulating tumor DNA in patient blood samples. The sequencing of the cancer genomes found in the patient blood samples may identify mutations in the cancer genome. These mutations may have an impact on the treatment outcomes and overall survival. We can analyze the mutations from your liquid biopsy sequencing results. Such analysis can help you understand the implications of such mutations and may help you determine any specific treatment options available. It also helps with expectation management. CANCER GENOMICS IS Pushing NEW BOUNDARIES Mutations in certain genes matter as it modulates the treatment outcome. Mutated protein-specific treatments are increasing with a lot of new drugs that are being approved by the FDA in recent years. ​ We can demystify the cancer genomics for you and unveil information that can help you with disease and expectation management. We can analyze your specific mutations identified through NexGen sequencing using bio-informatics and determine how the mutation affects the overall survival and disease-free survival from publicly available large scale data sets. ​ Contact us tellus@cancertherapies4u.com Go Back

  • Follow up cancer care | www.cancertherapies4u.com

    How to get the best follow-up care after cancer treatment? FOLLOW-UP CARE Follow-up care after cancer remission is important. It is important to monitor patient health for short term and long term effects of treatments. Most importantly, to monitor cancer relapse. Doctor visit - how often? According to NCI Every 3 - 4 months in the first 2 - 3 years once or twice a year after that Keep track of your follow up care plan It is recommended that you create your own follow-up care tracking plan, especially if you visit multiple health care providers. Different for everyone The frequency of your follow-up visits will depend on the type of cancer treatment received overall health treatment related issues ​ What to expect? According to NCI physical exams blood tests scans other tests We can help you create your own customized follow-up care database Easily keep track of your follow-up wellness plan. ​ Contact us via email tellus@cancertherapies4u.com Free resource from NCI https://www.cancer.gov/about-cancer/coping/survivorship/follow-up-care. Go Back

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